Method for inducing primitive endoderm from naive pluripotent stem cells
|Appl. No. (filing date)||PCT/JP2018/041243 (2018/11/06)|
|Pub. No. (Pub. date)||WO2019/093340 (2019/05/16)|
|Priority claim No. (Priority date)||
|Inventor||TAKASHIMA, Yasuhiro, etc.|
|Title of Invention||Method for inducing primitive endoderm from naive pluripotent stem cells|
Provided is Provided is a method for preparing primitive endoderm from naive pluripotent stem cells in vitro, comprising a step in which the naive pluripotent stem cells are cultured in a culture medium containing BMP and FGF4, and preferably further containing at least one substance selected from PDGF, IL-6, TGFβ inhibitor, Wnt signal inhibitor, and retinoic acid.