Method for evaluating cell hyperstimulation toxicity
|Appl. No. (filing date)||PCT/JP2018/043917 (2018/11/29)|
|Pub. No. (Pub. date)||WO2019/107481 (2019/06/06)|
|Priority claim No. (Priority date)||
|Inventor||INOUE, Haruhisa, etc.|
|Title of Invention||Method for evaluating cell hyperstimulation toxicity|
Provided is a method for evaluating hyperstimulation toxicity of a test substance to a human neurocyte, comprising (1) a step of bringing a test substance into contact with a human neurocyte differentiated from a pluripotent stem cell, (2) a step of stimulating the human neurocyte, (3) a step of measuring the degree of hyperstimulation of the human neurocyte, and (4) a step of evaluating that the test substance has hyperstimulation toxicity to a human neurocyte when the hyperstimulation of the human neurocyte is enhanced in the presence of the test substance.