Related Patent Info

REPROGRAMMING CELLS WITH SYNTHETIC MESSENGER RNA

Inventor WARREN, Luigi
Assignee WARREN, Luigi
Title of Invention REPROGRAMMING CELLS WITH SYNTHETIC MESSENGER RNA
Abstract

Provided is a method for accelerating cell lineage conversion (in a preferred embodiment, reprogramming a somatic cell into an iPS cell) comprising steps of transfecting a cell with a composition comprising at least one synthetic mRNA encoding an engineered chimeric transcription factor (in a preferred embodiment, based on Oct4 and/or Sox2 and/or Nanog) fused with a heterologous peptide sequence derived from the C-terminal transactivation domain (TAD) of Gal4.