Related Patent Info

PANCREATIC CELLS FOR TREATING DIABETES AND METHODS OF GENERATING THE SAME

Inventor RUST, William
Assignee SERAXIS, INC.
Title of Invention PANCREATIC CELLS FOR TREATING DIABETES AND METHODS OF GENERATING THE SAME
Abstract

Provided is a method for producing mammalian insulin-secreting cells, comprising steps of (i) culturing mammalian stem cells which may be iPS cells in a first medium comprising an endoderm-inducing factor, thereby differentiating the cells into endoderm cells, and (ii) culturing the endoderm cells from (i) in a second medium comprising an endocrine-inducing factor, thereby differentiating the cells into endocrine cells; wherein the mammalian stem cells are not exposed to KGF prior to differentiation into endoderm cells.