Related Patent Info
METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO INTESTINAL EPITHELIAL CELLS
| Inventor | MATSUNAGA Tamihide, etc. |
|---|---|
| Assignee | PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, etc. |
| Title of Invention | METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO INTESTINAL EPITHELIAL CELLS |
| Abstract | Present invention provides a novel and efficient method for differentiating pluripotent stem cells into intestinal epithelial cells, comprising steps of (1) differentiating the pluripotent stem cells into intestinal stem cell-like cells and (2) differentiating the intestinal stem cell-like cells obtained in step (1) into intestinal epithelial cell-like cells by using an MEK1 inhibitor, a DNA methylation inhibitor, a TGFβ receptor inhibitor, EGF and a cAMP activator. |