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FORMATION OF THREE-DIMENSIONAL ORGAN FROM PLURIPOTENT STEM CELLS

Inventor TANIGUCHI, Hideki, etc.
Assignee PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
Title of Invention FORMATION OF THREE-DIMENSIONAL ORGAN FROM PLURIPOTENT STEM CELLS
Abstract

Provided is a method for manufacturing an organ bud using (i) vascular cells, (ii) mesenchymal cells, and (iii) tissue or organ cells, wherein each of (i), (ii), and (iii) has been induced from human pluripotent stem cells. In a preferred embodiment, (iii) is a TBX3 and ADRA1B positive human iPSC-derived hepatocyte and the manufactured organ bud is a liver bud.