Related Patent Info
INDUCING MICROGLIA FROM HEMATOPOIETIC AND PLURIPOTENT STEM CELLS
| Inventor | ROSSI, Derrick, etc. |
|---|---|
| Assignee | CHILDREN'S MEDICAL CENTER CORPORATION |
| Title of Invention | INDUCING MICROGLIA FROM HEMATOPOIETIC AND PLURIPOTENT STEM CELLS |
| Abstract | Provided is a method for generating a microglia-like cell comprising steps of (i) differentiating an iPS cell (or, a hematopoietic stem cell or a CD34+ cell) into a monocyte, and (ii) differentiating the monocyte into a microglia-like cell, wherein the step (i) comprises contacting the cell with M-CSF, hSCF, Flt-3, hIL-3, or combinations thereof, and step (ii) comprises contacting the monocyte with GM-CSF and IL-34. |