Related Patent Info

GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE

Inventor RIECK, Sebastian, etc.
Assignee JANSSEN BIOTECH, INC.
Title of Invention GENERATION OF HUMAN PLURIPOTENT STEM CELL DERIVED FUNCTIONAL BETA CELLS SHOWING A GLUCOSE-DEPENDENT MITOCHONDRIAL RESPIRATION AND TWO-PHASE INSULIN SECRETION RESPONSE
Abstract

The invention provides a method for differentiating pancreatic endoderm cells into functional beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A by use of one or more small molecule(s) selected from a defined group. The said pancreatic endoderm cells may be obtained by step-wise differentiation from pluripotent stem cells.