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METHOD FOR GENERATING PROGENITOR T CELLS FROM STEM AND/OR PROGENITOR CELLS AND USE OF SAME

Inventor ZANDSTRA, Peter W, etc.
Assignee THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Title of Invention METHOD FOR GENERATING PROGENITOR T CELLS FROM STEM AND/OR PROGENITOR CELLS AND USE OF SAME
Abstract

The present disclosure provides a method for generating progenitor T cells from stem and/or progenitor cells comprising a step of exposing the stem and/or progenitor cells to Notch Ligand Delta- like-4 (DL4) and vascular adhesion molecule 1 (VCAM-1) under conditions suitable to generate progenitor T cells.