Related Patent Info

ISOGENIC BLOOD-BRAIN BARRIER MODEL

Inventor SHUSTA, Eric, V, etc.
Assignee WISCONSIN ALUMNI RESEARCH FOUNDATION, etc.
Title of Invention ISOGENIC BLOOD-BRAIN BARRIER MODEL
Abstract

Provided is a method for inducing blood brain barrier properties in iPSC-derived brain microvascular endothelial cells (BMECs) to generate an isogenic blood brain barrier model, comprising a step of co-culturing iPSC-derived BMECs with a cell type selected from the group consisting of iPSC-derived astrocytes, iPSC-derived neurons, and combinations thereof.