|Title of Invention||Method of improving the efficiency of iPS cell generation using Lin 28B with other reprogramming factors|
|Appl. No. (filing date)||PCT/JP2010/067016 (Sep 22, 2010)|
|No. of Publication Appl.(Publication date)||WO/2011/037270 (Mar 31, 2011)|
|Priority claim No. (Priority date)||61/245,478 (US) (Sep 24, 2009)|
|Abstract||This invention, in one major aspect, relates to a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid encoding the same together with other nuclear reprogramming factors to a somatic cell.|
|Comments||・This application is still in the international phase.
・When establishing iPS cells with (Oct3/4, Sox2, Klf4) and Lin28 or Lin28B, the effect of Lin28B in improving iPS cell establishment efficiency is equivalent to, or higher than, that of Lin28, and furthermore Lin28B is effective even on such cells on which Lin28 is ineffective (or little effective).