Patent Portfolio

Method for inducing exon skipping by genome editing

Ref. No. AJ145
Appl. No.
(filing date)
PCT/JP2017/041756(2017/11/21)
Pub. No.
(Pub. date)
WO2018/179578(2018/10/4)
Priority claim No.
(Priority date)

JP2017-068909 (2017/3/30)

Patent No.

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Inventor LI, Hongmei, etc.
Assignee Kyoto University
Title of Invention Method for inducing exon skipping by genome editing
Abstract

Provided is a method for skipping a target exon of a desired gene in a genome using CRISPR-Cas and a guide RNA, characterized in that said guide RNA has such a spacer sequence that the CRISPR-Cas cleavage site is positioned within 80 bases apart either from a splice donor site immediately before the target exon or from a splice acceptor site immediately after the target exon.

Comments

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Updated date 2018/11/16
Information
(External link)
https://www.j-platpat.inpit.go.jp/c1800/PU/WO-A-2018-179578/2887EF46D105D51D87C8A2E453C8FD8ED09C1176BC69BCB5B4C361C511D9625F/50/en
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